A neuroscientist's guide to future-proofing your brain and thinking smarter in the 21st Century

David Robson
News imageAdam Mracek A portrait of neuroscientist Hanna Critchlow, standing in a corridor (Credit: Adam Mracek)Adam Mracek
(Credit: Adam Mracek)

In her new book, The 21st Century Brain, scientist Hannah Critchlow explores the overlooked skills that will be necessary to flourish in the age of AI – and how we can cultivate them.

With the world around us evolving at an ever-greater pace, you may fantasise about upgrading your brain to make sense of it all. 

 At face value, this would seem impossible: our grey-and-white matter has largely the same structure as that of our ancestors living in the Stone Age. If anything, our brains are a bit smaller: archaeological remains suggest they have significantly shrunk in the past 10,000 years

Hannah Critchlow, a neuroscientist at the University of Cambridge, UK, offers many reasons to be optimistic, however. In her new book The 21st Century Brain she describes how we can all cultivate the mental flexibility that will be necessary to navigate the challenges ahead. 

"I basically wrote it for myself, so that I can make better decisions and improve my own life, especially as I go through middle age," she tells me. "But also for my parents, so that they can maintain a healthy brain into older age, and for my son, who's 10 now. What can I do to help his brain to flourish?" 

Read on to discover her secrets for future-proofing your mind. 

News imageGetty Images Taking a walk in nature may release the shackles on your thinking, freeing your creativity (Credit: Getty Images)Getty Images
Taking a walk in nature may release the shackles on your thinking, freeing your creativity (Credit: Getty Images)

What inspired you to explore the concept of the 21st Century Brain?

I first began working on the book three years ago, and in the intervening time, there's been an explosion of developments in AI. But it was obvious, even then, that this technology was going to start encroaching on all our lives, on a society-wide level, but also on an individual level – and then, as now, there was a lot of excitement about that, and a lot of fear.

I wanted to take a step back, and acknowledge the fact that AI was developed from knowledge that we've got from neuroscience. So what if we flip that around and ask how we can use this understanding to make the most of the intelligence that we have within our own organic brain? The same understanding that has driven these technological developments can unleash the human cognitive potential that we all have.

What were your criteria for selecting the skills that will be most important for the 21st Century?

I wanted to focus on the skills that have often been overlooked by scientists, but which underpin our ability to connect with each other, to imagine a new world, to innovate, to problem-solve, and to think longer term. Since we're living at a time of unprecedented change social and technological change, I examine our ability to tolerate change, uncertainty and ambiguity.

All of this basically requires healthy "bioenergetics", so I also look at the mitochondria – the power stations of our cells. 

Levels of altruism were altered by having a much more diverse gut microbiome. Isn't that incredible? – Hannah Critchlow

Let's start with emotional intelligence and empathy, which are often viewed as "soft skills". 

Emotional intelligence and empathy scores can be the biggest predictor of how satisfied we are with lifehow positive we feel about our relations with others and academic success.

When we look at the genetic data, it seems to have a heritability of between 10% and 45%, but we can all train our emotional intelligence and empathy. Jamil Zaki, a psychologist at Stanford University, argues that we can start by showing a little bit of compassion to ourselves. Just take time to ask, "Why am I feeling this emotion?" And what is it that I can do to help myself with this feeling, so that I'm more comfortable? Once you start practicing a little bit of self-compassion, the effects will ripple out to others.

You also argue that altruistic behaviour may – quite literally – come from our guts.

There is a really lovely study by Hilke Plassmann from Insead in Fontainebleau, France, and her colleagues, who looked at 100 healthy volunteers taking pre- and probiotics. After just seven weeks they had a more varied gut microbiome, compared to those taking the placebo, and they were also much more altruistic. The participants were more willing to relinquish their own money in the name of equality, for instance. In other words, their levels of altruism were altered by them having a much more diverse gut microbiome. Isn't that incredible? 

Indeed! How is it possible that our gut bacteria could change our behaviour? 

The mechanism is not entirely known, but there are loads of nerves that live within the gut and our heart. And when you get "gut feeling", that's because all of those cells are basically sending a signal up via the vagus nerve to the insula, which is the region of the brain that's involved in sensing our environment and collecting information, and then the decision-making parts of the brain. It's thought gut bacteria produce chemical neurotransmitters that alter the activity of neural circuits to shape our behaviour including social interactions. 

How about creativity? There's this amazing sentence in your book where you argue that, from a neuroscientist's point of view, the difference between a Wolfgang Amadeus Mozart or Ada Lovelace and the rest of us, is only one of slight degree. How can we make more of these talents?

One is to make the most of our daydreaming. Twenty percent of our day is spent mind-wandering – so not thinking about anything specifically, or trying to work on a particular goal – and that is when you start to get new ideas. Your brain just kind of settles on different things that are rumbling through your mind. And we know that just going out for a walk in nature can help with that process. It helps to increase a very particular frequency of electrical oscillations in the brain called alpha waves, which are associated with calm, creative thinking. It is probably why Archimedes also had his eureka moment in his bath, when he was nice and relaxed in the water. 

We also know that sleep is important for creativity, especially when you are first dropping off and thinking in a strange, fragmented way. Once again, it's encouraging the brainwaves that are associated with that enhanced creativity.

It's been said that Thomas Edison would hold a metal object over a metal tray, it would clatter down onto the metal tray and wake him up, so that he could scribble down any new ideas that he’d had.

News imageGetty Images Exercise can encourage the growth of neurons and neural connections, which will protect our brain as we age (Credit: Getty Images)Getty Images
Exercise can encourage the growth of neurons and neural connections, which will protect our brain as we age (Credit: Getty Images)

You make a strong case that keeping fit might also help us cope better with the challenges of the 21st Century. 

We know that physical activity is not only incredibly good for the body, but also for the brain, because it allows the creation of new nerve cells and circuits. That helps us to think in new ways and incorporate new bits of information, so that we retain that agility and flexibility within the brain.

Which brings us to bioenergetics. What is it, and how do you apply that knowledge in your own life?

It depends on our mitochondria – the tiny powerhouses in our cells. Our brain uses vast amounts of energy to think in different ways, and so, anything that we can do to help our mitochondria to create nice, clean energy is going to help with all of those mental gymnastics.

More like this:

I do exercise, because that helps mitochondria multiply, so that you've got more power stations in your brain and in your body. I make sure that I get enough sleep, because that's when you can mop up the toxic waste from the energy production. And I eat healthily, so that my mitochondria have got the right fuel to create the right type of energy. That means not eating too much sugar or processed food. 

Finally, what is your advice for someone who feels overwhelmed with the pace of life today? 

It's strange, because in some ways, the human brain struggles with change, and the uncertainty and ambiguity that comes with it. But as a species, we seem to have been driven to innovate and to move in different directions, to explore and be curious. So there's always been a tension between the two, and I think it's helpful to just accept that this is a part of our species' natural predisposition – to create change and to be slightly fearful of it. 

Hannah Critchlow's latest book The 21st Century Brain: Cutting Edge Neuroscience to Help Us Navigate the Future is published by Torva. 

* David Robson is an award-winning science writer and author. His latest book, The Laws of Connection: 13 Social Strategies That Will Transform Your Life, was published by Canongate (UK) and Pegasus Books (USA & Canada) in June 2024. He is @davidarobson on Instagram and Threads and writes the 60-Second Psychology newsletter on Substack.

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