Alyssa D'Inca (twice), Vittoria Zanette (twice) and Aura Muzzo score in first half for Italy, seeking first win of Six Nations campaign
Vittoria Vecchini adds to Italy's lead with sixth try
Hosts reduced to 13 players as Veronica Madia and Elisa Giordano are sent to sin-bin
Scotland take advantage to score through Lana Skeldon - but Italy add a try themselves through Giordana Duca while still two players down
Molly Poolman darts through to score Scotland's second try
Scotland captain Rachel Malcolm ruled out just before kick-off through injury
Have your say on the Women's Six Nations
Live Reporting
Tim Oscroft, Ella Gibbs and Joe Rindl
'We will reset and hopefully come back stronger'published at 18:50 BST
18:50 BST
FT: Italy 41-14 Scotland
Scotland captain Lana Skeldon: "I don't think we are quite there, we have not put in an 80 minute performance yet. You have seen glimpses of what we are capable of across the last three games. We are working to get that 80 minute performance, but it's not quite there yet."
(on the late changes to the lineup): "A reshuffle is different and a change, but it is an opportunity for other people to show what they are about and they did a great job. I have learnt a lot from today, and going forwards it will pay dividends if we end up in that situation."
"The fallow week is a good chance for a reset, winning or losing, we will just reset, recalibrate and hopefully come back stronger."
The Italy side and support staff are jubilant and celebrating on the pitch after their first win in the Six Nations since a 44-12 victory over Wales on 27 April last year.
They have also moved into third in the table on six points.
'Italy made Scotland look average'published at 18:36 BST
18:36 BST
FT: Italy 41-14 Scotland
Danielle Waterman Former England international on BBC iPlayer
I think there was a huge energy coming out from the blocks from the Italians, they were incredibly impressive. Their set-piece and determination in defence was brilliant. They made Scotland look average at times. They capitalised on every opportunity they got.
The main stand shadow is now reaching all the way across the pitch, only some of the corners are still in the sun but it's still a broiling evening in Parma.
Emma Wassell goes off for a HIA after taking a knock to the throat - the mouthguard system must have alerted on that after her head went back. She trotted off without looking distressed.
Sad to see such a hammering vs Italy. The heat, passionate home team/crowd, loads of top team injured and a new coach… Have concerns that, at the moment and for some time to come, this is a one team world game. It’s sad, despite the hype it won’t attract more popularity.
Danielle Waterman Former England international on BBC iPlayer
I think it would be a big ask to beat France. Rachel Malcolm will be hoping to get back on to the field.
I think France are definitely a beatable team, I'm calling a potentially Irish win this evening. There's still a lot (for Scotland) to scratch their heads about on this performance, though.
Spirit from Scotland as Fran McGhie slices down the right wing well into the Italian 22.
The ball is then spun left, but a you-shall-not-pass tackle from Emma Stevanin stops the attack 10 metres short, allowing Italy to hoof the ball towards halfway.