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Kick-off at 20:00 BST live from Accu Stadium
Bottom club Huddersfield host St Helens who are second in Super League, level on points with leaders Leeds Rhinos.
The Giants are led by interim head coach Liam Finn following the sacking of Luke Robinson in March.
They've won just two of ten league games this season and were dealt a huge blow this week with captain Adam Clune now side-lined for 3-4 months.
St Helens have won eight of their ten league games this year, but lost (0-32) in the semi-finals of the Challenge Cup last week to bitter rivals Wigan.
They've won their last five games in Super League and victory will, for 24 hours at least, put them top of the table.
Image source, Getty ImagesDate: Thursday 14 May Kick-off: 20:00 BST
Venue: Accu Stadium
Follow coverage on BBC iPlayer, BBC Radio 5 Live Sports Extra, BBC Radio Leeds and BBC Radio Merseyside from 19:30 BST.
Image source, Getty ImagesA general view of The John Smith's Stadium
The clash between Huddersfield Giants and St Helens tonight looks like a classic response game for the vistors.
St Helens head into Round 11 wounded after a heavy 32-0 Challenge Cup semi-final defeat to rivals Wigan Warriors at the weekend, but their Super League form before that had been excellent, with four straight league wins.
Huddersfield, meanwhile, are struggling near the foot of the table after losing eight of their first ten league matches and were beaten 34-4 by Warrington Wolves in their last outing.
Image source, Getty ImagesLee Kershaw
Huddersfield, currently 14th, have boosted their squad with the loan signing of Lee Kershaw from Castleford Tigers, with the winger in contention to feature.
Saints are expected to control possession and territory, but the Giants will hope home advantage and fresh energy can make things difficult.
